Oral leukoplakia is a white patch or plaque that develops in the oral cavity and is strongly associated with smoking. We report a case of a 65 year old male patient presenting with erythroplakia on the palate. Leukoplakia free download as powerpoint presentation. Oral proliferative verrucous leukoplakia pvl is a distinct subset of nonhomogenous leukoplakia. Mar 26, 2017 the main purpose of oral leukoplakia management is to avoid malignant transformation of the lesion or if this happened to detect this in early stages. Leukoplakia affects the mucous membranes of the mouth. Oral hairy leukoplakia is a disease of the oral mucosa that was first described in 1984.
Proliferative verrucous leukoplakia pvl is a rare oral leukoplakia and has four features such as chronic proliferation, multiple occurrences, refractoriness to treatment and high rate of malignant transformation. Leukoplakia causes, pictures, symptoms, treatment, prognosis. The primary outcomes of interest were clinical resolution, malignant transformation, followup, and recurrence of ol. Pada tipe ini, terutama berupa lesi putih yang datar dan. View reference source for the article along with the name of the writer and the editor for the article on leukoplakia. Analysis of leukoplakia disease classification using radial. Important research into oral and oropharyngeal cancers is taking place in many university hospitals, medical centers, and other institutions around the country. The condition is thought to be caused by irritation, but the cause is not always known. As mentioned above, most pvl cases processed to malignancy over many years, sometimes 20 years. A modifed classification and staging system for oral leukoplakia article pdf available in oral oncology 363.
Now customize the name of a clipboard to store your clips. Each year, scientists find out more about what causes the disease, how to prevent it, and how to improve treatment. Leukoplakia and erythroplakia of the oral mucosa a brief. Leukoplakia, precancerous tumour of the mucous membranes, usually seen in the mouth or on the tongue or cheeks, but also known to occur on the lips, as well as on the vagina, vulva, or anus. However, leukoplakia is not limited as an oral disorder alone, as it may also appear in the genital area of the female. Leukoplakia, management, surgical, nonsurgical treatment, download full text pdf 512 kb please cite this article in pubmed style or ama american medical association style. They are commonly seen in smokers, individuals exposed to toxic irritants, and patients with nutritional deficiencies but they also occur in. The most frequent location for leukoplakia was the buccal mucosa 28. The typical benign leukoplakia is also dealt with separately. The aim of this paper was to assess the nonsurgical treatment of oral leukoplakia ol. Clipping is a handy way to collect important slides you want to go back to later.
A modifed classification and staging system for oral leukoplakia. Epidemiological and clinicopathological study of oral leukoplakia. Started multivitamins and it reversed about 95% cured. Oral hairy leukoplakia can also appear in other people whose immune system is not working well, such as after a bone marrow transplant.
Leukoplakia is a relatively common clinical finding in clinical medicine. Although the sores can vary in appearance, they are usually white or gray. Leukoplakia has various appearances and changes can usually develop on the gums, the inside of cheeks, and the bottom of the mouth as well as often on the tongue and can also appear as. Leukoplakia definition of leukoplakia by medical dictionary. This highlights the need for routine serologic testing for syphilis in all cases of hairy oral leukoplakia, particularly in patients with hiv infection. Note that the extent of the lesion, as seen by loss of green autofluorescence, is bigger than the clinical lesion seen by the unaided eye in fig. Images of epsteinbarr virus ebvoral hairy leukoplakia ohl, from the va hivaids website. Leucoplasia pilosa oral the isolate of nonhaemolytic streptococcus showed full susceptibility aqueous and ethanolic extracts bidens pilosa ceftriaxone. They may appear shaggy or contain a number of tiny folds or ridges. Small lesions can be helped through regular checkups and followups and the patient must also take responsibility for regularly inspecting his or her own mouth for any suspicious growths that may look abnormal. Terdapat beberapa tipe klinis leukoplakia, antara lain. Linking all these considerations we hereby aim to propose guidelinesfor appropriate management of oral leukoplakia in indian scenario. Leukoplakia luke o plake ee ah is a clinical term that is used to describe certain white patches in the mouth. Leukoplakia, management, surgical, nonsurgical treatment, introduction oral leukoplakia ol is the most frequent precancerous lesion of the oral cavity.
As far as the academic sources are concerned, clinical leukoplakia is a jumping to conclusions, just like clinicians who immediately call a lesion hypertrophic or. Leukoplakia can be relatively harmless if the condition is caught early enough. This is a disorder which is most generally found in the elderly. Oral hairy leukoplakia pictures, causes, treatment, symptoms. The prognosis and overall survival of a patient with oral cancer is dependent on the early detection of any lesion that might identify a patient with higher risk than normal or with early infiltration before metastatic disease. Oral leukoplakia list of high impact articles ppts.
Leukoplakia may be etymologically derived from white patch in greek, but not all white patches are rightfully called leukoplakia. Oral hairy leukoplakia refers to a white patch that forms in the mouth. Leukoplakia is a condition wherein white or gray patches appear in some parts of the mouth, predominantly in the buccal mucosa and the tongue. The rate of malignant transformation is not definitively known, but reports in the literature range widely from 0. This article looks at leukoplakia of the head and neck. Oral leukoplakia ol is a white patch or plaque of the oral mucosa that cannot be characterised clinically or pathologically as any other condition such as cheek biting, candidosis, lichen planus and materia alba. Leukoplakia genetic and rare diseases information center. Oct 09, 2015 a combination of the 1978 and the 2005 who definitions of oral leukoplakia may result in the following text. Leukoplakia is defined as a white patch or plaque that cannot be ascribed to any other clinical disease.
A significant number of cases with erythroplakia progress to carcinoma. A combination of the 1978 and the 2005 who definitions of oral leukoplakia may result in the following text. Insight of various medical management of oral leukoplakia. Leukoplakia and erythroplakia are the two most common potentially malignant disorders of the oral cavity. Ol is premalignant and is associated with squamous cell carcinoma scc. For this purpose, 42 hivinfected patients were selected, with 69 oral hairy leukoplakia treated at orestes diniz. Kanmani2, n megalai3 1department of oral medicine and radiology, indira gandhi institute of dental sciences, pondicherry, india. However, this report described a case of rapid progress, which had malignant. On the basis of the lowest reported annual malignant transformation rate of oral leukoplakia, it can be calculated that patients with oral leukoplakia. Case report of rapidly progressive proliferative verrucous. Not all white patches are called leukoplakia just the ones that cannot be rubbed off and cannot be diagnosed as any other condition or disease figures 14. Leukoplakia and erythroplakia sean parker institute for the. Most patches of leukoplakia are benign, but a small number can show early cancer symptoms, and numerous mouth cancers develop beside the areas of leukoplakia. Oct 23, 2018 oral hairy leukoplakia refers to a white patch that forms in the mouth.
Oral leukoplakia ol is the most frequent potentially malignant disorder of oral mucosa. A type of leukoplakia of the mouth, called oral hairy leukoplakia, is caused by the epsteinbarr virus. Biopsy and histopathologic diagnosis of oral premalignant. The main purpose of oral leukoplakia management is to avoid malignant transformation of the lesion or if this happened to detect this in early stages. Secondary syphilis simulating oral hairy leukoplakia.
It has been defined as a predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion. These patches usually appear along the sides of the tongue, or on the top and underside of the tongue or along the inside of the cheek. Leukoplakia is a response to longterm irritation and is a precancerous condition that should never be ignored. James hargan, university of kentucky college of medicine answered sep. Leukoplakia are patches on the tongue, in the mouth, or on the inside of the cheek. Leukoplakia homogen dalam perkembangannya, leukoplakia dapat menjadi semakin meluas, menebal, disebut leukoplakia homogen. Also the hyper keratinisation is seen on the superficial aspect. This function is accomplished through a ligation between betacarotene and oxygen, which is an unstable reactive molecule, thus diminishing the damaging effects of free radicals lycopene in vitro experiments have shown the inhibition of the process of human neoplastic cellular growth by lycopene, since this. Smoking or other tobacco use smokers keratosis, especially pipes. Mar, 2019 oral leukoplakia ol is a white patch or plaque that cannot be rubbed off, cannot be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco. The rate of malignant transformation is not definitively known. I was dignosed with leukoplakia on left side tongue by xxxxxxx ent in december 2009. Grayish or white patches which can not be wiped away. Apply for and manage the va benefits and services youve earned as a veteran, servicemember, or family memberlike health care, disability, education, and more.
Oral leukoplakia, the ongoing discussion on definition and. Therefore, it is advised to see the dentist if an individual has persistent, unusual changes in the mouth. Erythroplakia is predominantly a disease of the middle aged to older adults, with no signi. Leukoplakia juga dapat berkembang dan berubah bentuk menjadi eritroplakia. Therefore, a process of exclusion establishes the diagnosis of the disease. They are commonly seen in smokers, individuals exposed to toxic irritants, and patients with nutritional deficiencies but they also occur in the absence of such factors. A predominantly white patch or plaque that cannot be characterized clinically or pathologically as any other disorder. Leukoplakia and erythroplakia are lesions observed most frequently on the mucosa of the mouth, but also on occasion in the throat and on the vocal folds. Oral leukoplakia ol is a white patch or plaque that cannot be rubbed off, cannot be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco. Leukoplakia has long been known to be a precancerous lesion for oral squamous cell carcinoma. Biopsy and histopathologic diagnosis of oral premalignant and. This result should be interpreted with great caution since. Leucoplasia pilosa in english spanishenglish dictionary. Leukoplakia could be classified as mucosal disease, and also as a premalignant condition.
Although the white color in leukoplakia is a result of hyperkeratosis or acanthosis, similarly appearing white lesions that are caused by reactive keratosis smokers keratosis or frictional keratoses e. Jan 29, 20 oral leukoplakia ol is the most frequent potentially malignant disorder of oral mucosa. Relation of oral hairy leukoplakia to infection with the human immunodeficiency virus and the risk of developing aids. Oral leukoplakia ol is one among important potentially malignant disorder pmd of the oral mucosa. Leukoplakia is typically not hazardous, but it often can be serious. Jan 29, 2019 here my blog where i share pdf files with my readers.